Humanization of the mouse mammary gland by replacement of the luminal layer with genetically-engineered preneoplastic human cells

INTRODUCTION: The cell of origin for estrogen receptor α (ERα) positive breast cancer is probably a luminal stem cell in the terminal duct lobular units. To model these cells we have used the murine myoepithelial layer in the mouse mammary ducts as a scaffold upon which to build a human luminal laye...

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Dettagli Bibliografici
Pubblicato in:Breast Cancer Res
Autori principali: Verbeke, Stephanie, Richard, Elodie, Monceau, Elodie, Schmidt, Xenia, Rousseau, Benoit, Velasco, Valerie, Bernard, David, Bonnefoi, Herve, MacGrogan, Gaetan, Iggo, Richard D
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4407301/
https://ncbi.nlm.nih.gov/pubmed/25527189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-014-0504-9
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