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TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity
The genes and pathways that fine-tune TLR7-mediated innate inflammatory responses remain to be fully elucidated. Using an unbiased genome-scale shRNA screen, we identified the receptor TREML4 as an essential positive regulator of TLR7 signaling. Macrophages from Treml4(–/–) mice were hyporesponsive...
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| Publié dans: | Nat Immunol |
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| Auteurs principaux: | , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4406861/ https://ncbi.nlm.nih.gov/pubmed/25848864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3143 |
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