TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity

The genes and pathways that fine-tune TLR7-mediated innate inflammatory responses remain to be fully elucidated. Using an unbiased genome-scale shRNA screen, we identified the receptor TREML4 as an essential positive regulator of TLR7 signaling. Macrophages from Treml4(–/–) mice were hyporesponsive...

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Bibliografske podrobnosti
izdano v:Nat Immunol
Main Authors: Ramirez-Ortiz, Zaida G., Prasad, Amit, Griffith, Jason W., Pendergraft, William F., Cowley, Glenn S., Root, David E., Tai, Melissa, Luster, Andrew D., Khoury, Joseph El, Hacohen, Nir, Means, Terry K.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406861/
https://ncbi.nlm.nih.gov/pubmed/25848864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3143
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