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Genetic analyses benefit from using less heterogeneous phenotypes: An illustration with the Hospital Anxiety and Depression Scale (HADS)

Phenotypic heterogeneity of depression has been cited as one of causes of the limited success to detect genetic variants in genome-wide studies. The 7-item Hospital Anxiety and Depression Scale (HADS-D) was developed to detect depression in individuals with physical health problems. An initial psych...

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Vydáno v:Genet Epidemiol
Hlavní autoři: Laurin, Charles A., Hottenga, Jouke-Jan, Willemsen, Gonneke, Boomsma, Dorret I., Lubke, Gitta H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406831/
https://ncbi.nlm.nih.gov/pubmed/25832296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.21897
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