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Evidence that mutation accumulation does not cause aging in Saccharomyces cerevisiae

The concept that mutations cause aging phenotypes could not be directly tested previously due to inability to identify age-related mutations in somatic cells and determine their impact on organismal aging. Here, we subjected Saccharomyces cerevisiae to multiple rounds of replicative aging and assess...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Kaya, Alaattin, Lobanov, Alexei V, Gladyshev, Vadim N
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406665/
https://ncbi.nlm.nih.gov/pubmed/25702753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12290
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