Cyclin O (Ccno) functions during deuterosome-mediated centriole amplification of multiciliated cells

Mucociliary clearance and fluid transport along epithelial surfaces are carried out by multiciliated cells (MCCs). Recently, human mutations in Cyclin O (CCNO) were linked to severe airway disease. Here, we show that Ccno expression is restricted to MCCs and the genetic deletion of Ccno in mouse lea...

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Bibliografiske detaljer
Udgivet i:EMBO J
Main Authors: Funk, Maja C, Bera, Agata N, Menchen, Tabea, Kuales, Georg, Thriene, Kerstin, Lienkamp, Soeren S, Dengjel, Jörn, Omran, Heymut, Frank, Marcus, Arnold, Sebastian J
Format: Artigo
Sprog:Inglês
Udgivet: BlackWell Publishing Ltd 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406653/
https://ncbi.nlm.nih.gov/pubmed/25712475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201490805
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