Cyclin O (Ccno) functions during deuterosome-mediated centriole amplification of multiciliated cells

Mucociliary clearance and fluid transport along epithelial surfaces are carried out by multiciliated cells (MCCs). Recently, human mutations in Cyclin O (CCNO) were linked to severe airway disease. Here, we show that Ccno expression is restricted to MCCs and the genetic deletion of Ccno in mouse lea...

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Vydáno v:EMBO J
Hlavní autoři: Funk, Maja C, Bera, Agata N, Menchen, Tabea, Kuales, Georg, Thriene, Kerstin, Lienkamp, Soeren S, Dengjel, Jörn, Omran, Heymut, Frank, Marcus, Arnold, Sebastian J
Médium: Artigo
Jazyk:Inglês
Vydáno: BlackWell Publishing Ltd 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406653/
https://ncbi.nlm.nih.gov/pubmed/25712475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201490805
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