The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1β

Obesity is a major global public health problem, and understanding its pathogenesis is critical for identifying a cure. In this study, a gene knockout strategy was used in post-neonatal mice to delete synoviolin (Syvn)1/Hrd1/Der3, an ER-resident E3 ubiquitin ligase with known roles in homeostasis ma...

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Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:EMBO J
Κύριοι συγγραφείς: Fujita, Hidetoshi, Yagishita, Naoko, Aratani, Satoko, Saito-Fujita, Tomoko, Morota, Saori, Yamano, Yoshihisa, Hansson, Magnus J, Inazu, Masato, Kokuba, Hiroko, Sudo, Katsuko, Sato, Eiichi, Kawahara, Ko-ichi, Nakajima, Fukami, Hasegawa, Daisuke, Higuchi, Itsuro, Sato, Tomoo, Araya, Natsumi, Usui, Chie, Nishioka, Kenya, Nakatani, Yu, Maruyama, Ikuro, Usui, Masahiko, Hara, Naomi, Uchino, Hiroyuki, Elmer, Eskil, Nishioka, Kusuki, Nakajima, Toshihiro
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: BlackWell Publishing Ltd 2015
Θέματα:
Articles
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406651/
https://ncbi.nlm.nih.gov/pubmed/25698262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201489897
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