Phase I study of cladribine, cytarabine, granulocyte colony stimulating factor (CLAG regimen) and midostaurin and all-trans retinoic acid in relapsed/refractory AML

We conducted a phase 1 study using midostaurin (25 mg or 50 mg orally twice daily), all-trans retinoic acid (ATRA) and CLAG chemotherapy to target multiple pathways in relapsed/refractory AML. 10 patients received the combination and no dose limiting toxicities were observed. Two patients (22%) achi...

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Publicado en:Int J Hematol
Autores principales: Ramsingh, Giridharan, Westervelt, Peter, McBride, Ali, Stockerl-Goldstein, Keith, Vij, Ravi, Uy, Geoffrey, Cashen, Amanda, DiPersio, John F., Abboud, Camille N.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406413/
https://ncbi.nlm.nih.gov/pubmed/24488798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12185-014-1503-4
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