Disruption of the Golgi apparatus by brefeldin A blocks cell polarization and inhibits directed cell migration.
The role of the Golgi apparatus in the motile activity of fibroblasts was examined with brefeldin A (BFA), which disrupts the Golgi apparatus in a variety of cells. Upon incubation with BFA, Swiss mouse 3T3 fibroblasts lost their typical polarized morphology, in which the leading edge is characteriz...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1994
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44061/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8202549/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.12.5686 |
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