A novel thromboxane A(2) receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesis

We investigated the cause of mild mucocutaneous bleeding in a 14-year-old male patient (P1). Platelet aggregation and ATP secretion induced by arachidonic acid and the thromboxane A(2) receptor (TxA(2)R) agonist U46619 were reduced in P1 compared with controls, whereas the responses to other platele...

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Bibliografiska uppgifter
I publikationen:Blood
Huvudupphovsmän: Mumford, Andrew D., Dawood, Ban B., Daly, Martina E., Murden, Sherina L., Williams, Michael D., Protty, Majd B., Spalton, Jennifer C., Wheatley, Mark, Mundell, Stuart J., Watson, Steve P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405764/
https://ncbi.nlm.nih.gov/pubmed/19828703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-08-236976
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