Increased mitochondrial emission of reactive oxygen species and calpain activation are required for doxorubicin-induced cardiac and skeletal muscle myopathy

Although doxorubicin (DOX) is a highly effective anti-tumour agent used to treat a variety of cancers, DOX administration is associated with significant side effects, including myopathy of both cardiac and skeletal muscles. The mechanisms responsible for DOX-mediated myopathy remain a topic of debat...

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Detalhes bibliográficos
Publicado no:J Physiol
Main Authors: Min, Kisuk, Kwon, Oh-Sung, Smuder, Ashley J, Wiggs, Michael P, Sollanek, Kurt J, Christou, Demetra D, Yoo, Jeung-Ki, Hwang, Moon-Hyon, Szeto, Hazel H, Kavazis, Andreas N, Powers, Scott K
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Muscle
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405757/
https://ncbi.nlm.nih.gov/pubmed/25643692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2014.286518
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