Tartaric Acid-based Amphiphilic Macromolecules with Ether Linkages Exhibit Enhanced Repression of Oxidized Low Density Lipoprotein Uptake

Cardiovascular disease initiates with the atherogenic cascade of scavenger receptor- (SR-) mediated oxidized low-density lipoprotein (oxLDL) uptake. Resulting foam cell formation leads to lipid-rich lesions within arteries. We designed amphiphilic macromolecules (AMs) to inhibit these processes by c...

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Veröffentlicht in:Biomaterials
Hauptverfasser: Abdelhamid, Dalia, Zhang, Yingue, Lewis, Daniel R., Moghe, Prabhas V., Welsh, William J., Uhrich, Kathryn E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405674/
https://ncbi.nlm.nih.gov/pubmed/25890704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2015.02.038
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