Soluble VCAM-1 impairs human brain endothelial barrier integrity via integrin α-4-transduced outside-in signalling

Human brain microvascular endothelial cells forming the blood–brain barrier (BBB) release soluble vascular cell adhesion molecule-1 (sVCAM-1) under inflammatory conditions. Furthermore, sVCAM-1 serum levels in untreated patients with multiple sclerosis (MS) correlate with a breakdown of the BBB as m...

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Détails bibliographiques
Publié dans:Acta Neuropathol
Auteurs principaux: Haarmann, Axel, Nowak, Eva, Deiß, Annika, van der Pol, Susanne, Monoranu, Camelia-Maria, Kooij, Gijs, Müller, Nora, van der Valk, Paul, Stoll, Guido, de Vries, Helga E., Berberich-Siebelt, Friederike, Buttmann, Mathias
Format: Artigo
Langue:Inglês
Publié: Springer Berlin Heidelberg 2015
Sujets:
Original Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405352/
https://ncbi.nlm.nih.gov/pubmed/25814153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-015-1417-0
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