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Toll-like receptor 8 deletion accelerates autoimmunity in a mouse model of lupus through a Toll-like receptor 7-dependent mechanism

Systemic lupus erythematosus is an autoimmune disorder characterized by increased levels of lymphocyte activation, antigen presentation by dendritic cells, and the formation of autoantibodies. This leads to immune complex-mediated glomerulonephritis. Toll-like receptor 7 (T7) and TLR9 localize to th...

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Detalhes bibliográficos
Publicado no:Immunology
Main Authors: Tran, Ngoc Lan, Manzin-Lorenzi, Céline, Santiago-Raber, Marie-Laure
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405324/
https://ncbi.nlm.nih.gov/pubmed/25424423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12426
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