Tregs activated by bispecific antibodies: Killers or suppressors?

In recent years, bispecific antibodies (bsAb) have emerged as promising tools for a target-specific redirection of T cells in order to eliminate malignant cells. However, CD3-engaging constructs might also activate T regulatory cells (Tregs) present in the tumor microenvironment. Whether this has de...

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Bibliografiske detaljer
Udgivet i:Oncoimmunology
Main Authors: Koristka, Stefanie, Cartellieri, Marc, Arndt, Claudia, Feldmann, Anja, Seliger, Barbara, Ehninger, Gerhard, Bachmann, Michael P.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404924/
https://ncbi.nlm.nih.gov/pubmed/25949920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/2162402X.2014.994441
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