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miR-23a blockade enhances adoptive T cell transfer therapy by preserving immune-competence in the tumor microenvironment
In adoptive T cell transfer therapy (ACT), the antitumor efficacy of cytotoxic CD8(+) T lymphocytes (CTLs) has been limited by tumor-induced immunosuppression. We have demonstrated that miR-23a blockade in tumor-specific CTLs conferred resilience to TGFβ-mediated immunosuppression, resulting in supe...
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| Published in: | Oncoimmunology |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Taylor & Francis
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4404905/ https://ncbi.nlm.nih.gov/pubmed/25949909 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/2162402X.2014.990803 |
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