Metabolic perturbation sensitizes human breast cancer to NK cell-mediated cytotoxicity by increasing the expression of MHC class I chain-related A/B

Cleavage or shedding of the surface antigen, MHC class I chain-related (MIC) protein (A/B) has been known to be one of the mechanisms by which tumor cells escape host immune surveillance. Thus, any strategy to augment the surface expression of MICA/B could facilitate anticancer immune response. Here...

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Publicado en:Oncoimmunology
Autores principales: Fu, Dexue, Geschwind, Jean-Francois, Karthikeyan, Swathi, Miller, Eliyahu, Kunjithapatham, Rani, Wang, Zhijun, Ganapathy-Kanniappan, Shanmugasundaram
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2015
Materias:
Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404839/
https://ncbi.nlm.nih.gov/pubmed/25949910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/2162402X.2014.991228
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