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Sunitinib depletes myeloid-derived suppressor cells and synergizes with a cancer vaccine to enhance antigen-specific immune responses and tumor eradication

The high efficacy of therapeutic cancer vaccines in preclinical studies has yet to be fully achieved in clinical trials. Tumor immune suppression is a critical factor that hampers the desired antitumor effect. Here, we analyzed the combined effect of a cancer vaccine and the receptor tyrosine kinase...

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Bibliografske podrobnosti
izdano v:Oncoimmunology
Main Authors: Draghiciu, Oana, Nijman, Hans W, Hoogeboom, Baukje Nynke, Meijerhof, Tjarko, Daemen, Toos
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404834/
https://ncbi.nlm.nih.gov/pubmed/25949902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/2162402X.2014.989764
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