Aβ-induced degradation of BMAL1 and CBP leads to circadian rhythm disruption in Alzheimer’s disease

BACKGROUND: Patients with Alzheimer’s disease (AD) frequently experience disruption of their circadian rhythms, but whether and how circadian clock molecules are perturbed by AD remains unknown. AD is an age-related neurological disorder and amyloid-β (Aβ) is one of major causative molecules in the...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Song, Hyundong, Moon, Minho, Choe, Han Kyoung, Han, Dong-Hee, Jang, Changhwan, Kim, Ahbin, Cho, Sehyung, Kim, Kyungjin, Mook-Jung, Inhee
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404698/
https://ncbi.nlm.nih.gov/pubmed/25888034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-015-0007-x
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