TIM-3/Gal-9 interaction induces IFNγ-dependent IDO1 expression in acute myeloid leukemia blast cells

NK cells expressing TIM-3 show a marked increase in IFNγ production in response to acute myeloid leukemia (AML) blast cells that endogenously express Gal-9. Herein, we demonstrate that NK cell-mediated production of IFNγ, induced by TIM-3/Gal-9 interaction and released in bone marrow microenvironmen...

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Publicado en:J Hematol Oncol
Autores principales: Folgiero, Valentina, Cifaldi, Loredana, Pira, Giuseppina Li, Goffredo, Bianca Maria, Vinti, Luciana, Locatelli, Franco
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2015
Materias:
Letter to the Editor
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404691/
https://ncbi.nlm.nih.gov/pubmed/25886742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-015-0134-4
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