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IFN-γ induced IDO and WRS expression in microglia is differentially regulated by IL-4
Indoleamine 2,3-dioxygenase (IDO), a tryptophan catabolizing enzyme, has been implicated in the pathogenesis of various neurological disorders. IDO expression is induced by IFN-γ and leads to neurotoxicity by generating quinolinic acid. Additionally, it inhibits the immune response through both tryp...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2486430/ https://ncbi.nlm.nih.gov/pubmed/17661345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.20544 |
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