Non-crossover gene conversions show strong GC bias and unexpected clustering in humans

Although the past decade has seen tremendous progress in our understanding of fine-scale recombination, little is known about non-crossover (NCO) gene conversion. We report the first genome-wide study of NCO events in humans. Using SNP array data from 98 meioses, we identified 103 sites affected by...

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Vydáno v:eLife
Hlavní autoři: Williams, Amy L, Genovese, Giulio, Dyer, Thomas, Altemose, Nicolas, Truax, Katherine, Jun, Goo, Patterson, Nick, Myers, Simon R, Curran, Joanne E, Duggirala, Ravi, Blangero, John, Reich, David, Przeworski, Molly
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2015
Témata:
Genes and Chromosomes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404656/
https://ncbi.nlm.nih.gov/pubmed/25806687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.04637
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