Role of the NLRP3 inflammasome in the transient release of IL-1β induced by monosodium urate crystals in human fibroblast-like synoviocytes

BACKGROUND: To investigate whether monosodium urate (MSU) crystals induce interleukin (IL)-1β in human fibroblast-like synoviocytes (FLS), and whether the NLRP3 inflammasome is involved in the inflammatory mechanism. METHODS: Human FLS isolated from explants of synovial tissue were stimulated with M...

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Bibliographic Details
Published in:J Inflamm (Lond)
Main Authors: Zheng, Shu-cong, Zhu, Xiao-xia, Xue, Yu, Zhang, Li-hong, Zou, He-jian, Qiu, Jian-hua, Liu, Qiong
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403983/
https://ncbi.nlm.nih.gov/pubmed/25897296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12950-015-0070-7
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