Oxidation increases mucin polymer cross-links to stiffen airway mucus gels

Airway mucus in cystic fibrosis (CF) is highly elastic, but the mechanism behind this pathology is unclear. We hypothesized that the biophysical properties of CF mucus are altered because of neutrophilic oxidative stress. Using confocal imaging, rheology, and biochemical measures of inflammation and...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Yuan, Shaopeng, Hollinger, Martin, Lachowicz-Scroggins, Marrah E., Kerr, Sheena C., Dunican, Eleanor M., Daniel, Brian M., Ghosh, Sudakshina, Erzurum, Serpel C., Willard, Belinda, Hazen, Stanley L., Huang, Xiaozhu, Carrington, Stephen D., Oscarson, Stefan, Fahy, John V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403633/
https://ncbi.nlm.nih.gov/pubmed/25717100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3010525
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