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Oxidation increases mucin polymer cross-links to stiffen airway mucus gels
Airway mucus in cystic fibrosis (CF) is highly elastic, but the mechanism behind this pathology is unclear. We hypothesized that the biophysical properties of CF mucus are altered because of neutrophilic oxidative stress. Using confocal imaging, rheology, and biochemical measures of inflammation and...
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| 出版年: | Sci Transl Med |
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| 主要な著者: | , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4403633/ https://ncbi.nlm.nih.gov/pubmed/25717100 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3010525 |
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