Oxidation increases mucin polymer cross-links to stiffen airway mucus gels

Airway mucus in cystic fibrosis (CF) is highly elastic, but the mechanism behind this pathology is unclear. We hypothesized that the biophysical properties of CF mucus are altered because of neutrophilic oxidative stress. Using confocal imaging, rheology, and biochemical measures of inflammation and...

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Vydáno v:Sci Transl Med
Hlavní autoři: Yuan, Shaopeng, Hollinger, Martin, Lachowicz-Scroggins, Marrah E., Kerr, Sheena C., Dunican, Eleanor M., Daniel, Brian M., Ghosh, Sudakshina, Erzurum, Serpel C., Willard, Belinda, Hazen, Stanley L., Huang, Xiaozhu, Carrington, Stephen D., Oscarson, Stefan, Fahy, John V.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403633/
https://ncbi.nlm.nih.gov/pubmed/25717100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3010525
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