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Pcf11 orchestrates transcription termination pathways in yeast

In Saccharomyces cerevisiae, short noncoding RNA (ncRNA) generated by RNA polymerase II (Pol II) are terminated by the NRD complex consisting of Nrd1, Nab3, and Sen1. We now show that Pcf11, a component of the cleavage and polyadenylation complex (CPAC), is also generally required for NRD-dependent...

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Publicado en:Genes Dev
Autores principales: Grzechnik, Pawel, Gdula, Michal Ryszard, Proudfoot, Nick J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403260/
https://ncbi.nlm.nih.gov/pubmed/25877920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.251470.114
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