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One-pot refolding of core histones from bacterial inclusion bodies allows rapid reconstitution of histone octamer

We report an optimized method to purify and reconstitute histone octamer, which utilizes high expression of histones in inclusion bodies but eliminates the time consuming steps of individual histone purification. In the newly modified protocol, Xenopus laevis H2A, H2B, H3, and H4 are expressed indiv...

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Detalles Bibliográficos
Publicado en:Protein Expr Purif
Main Authors: Lee, Young-Tae, Gibbons, Garrett, Lee, Shirley Y., Nikolovska-Coleska, Zaneta, Dou, Yali
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403241/
https://ncbi.nlm.nih.gov/pubmed/25687285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pep.2015.02.007
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