Multiple mechanisms limit meiotic crossovers: TOP3α and two BLM homologs antagonize crossovers in parallel to FANCM

Meiotic crossovers (COs) have two important roles, shuffling genetic information and ensuring proper chromosome segregation. Despite their importance and a large excess of precursors (i.e., DNA double-strand breaks, DSBs), the number of COs is tightly regulated, typically one to three per chromosome...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Séguéla-Arnaud, Mathilde, Crismani, Wayne, Larchevêque, Cécile, Mazel, Julien, Froger, Nicole, Choinard, Sandrine, Lemhemdi, Afef, Macaisne, Nicolas, Van Leene, Jelle, Gevaert, Kris, De Jaeger, Geert, Chelysheva, Liudmilla, Mercier, Raphael
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2015
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403193/
https://ncbi.nlm.nih.gov/pubmed/25825745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1423107112
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