SOX2 primes the epigenetic landscape in neural precursors enabling proper gene activation during hippocampal neurogenesis

Newborn granule neurons generated from neural progenitor cells (NPCs) in the adult hippocampus play a key role in spatial learning and pattern separation. However, the molecular mechanisms that control activation of their neurogenic program remain poorly understood. Here, we report a novel function...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Amador-Arjona, Alejandro, Cimadamore, Flavio, Huang, Chun-Teng, Wright, Rebecca, Lewis, Susan, Gage, Fred H., Terskikh, Alexey V.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403144/
https://ncbi.nlm.nih.gov/pubmed/25825708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1421480112
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