A high-throughput RNAi screen for detection of immune-checkpoint molecules that mediate tumor resistance to cytotoxic T lymphocytes

The success of T cell-based cancer immunotherapy is limited by tumor's resistance against killing by cytotoxic T lymphocytes (CTLs). Tumor-immune resistance is mediated by cell surface ligands that engage immune-inhibitory receptors on T cells. These ligands represent potent targets for therape...

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Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Khandelwal, Nisit, Breinig, Marco, Speck, Tobias, Michels, Tillmann, Kreutzer, Christiane, Sorrentino, Antonio, Sharma, Ashwini Kumar, Umansky, Ludmila, Conrad, Heinke, Poschke, Isabel, Offringa, Rienk, König, Rainer, Bernhard, Helga, Machlenkin, Arthur, Boutros, Michael, Beckhove, Philipp
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403046/
https://ncbi.nlm.nih.gov/pubmed/25691366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201404414
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