AAV-8 Is More Efficient than AAV-9 in Transducing Neonatal Dog Heart

Adeno-associated virus serotype-8 and 9 (AAV-8 and 9) are the leading candidate vectors to test bodywide neonatal muscle gene therapy in large mammals. We have previously shown that systemic injection of 2–2.5×10(14) viral genome (vg) particles/kg of AAV-9 resulted in widespread skeletal muscle gene...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Hum Gene Ther Methods
Prif Awduron: Pan, Xiufang, Yue, Yongping, Zhang, Keqing, Hakim, Chady H., Kodippili, Kasun, McDonald, Thomas, Duan, Dongsheng
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Mary Ann Liebert, Inc. 2015
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403016/
https://ncbi.nlm.nih.gov/pubmed/25763686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hgtb.2014.128
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