Interrogating the Aged Striatum: Robust Survival of Grafted Dopamine Neurons in Aging Rats Produces Inferior Behavioral Recovery and Evidence of Impaired Integration

Advanced age is the primary risk factor for Parkinson disease (PD). In PD patients and rodent models of PD, advanced age is associated with inferior symptomatic benefit following intrastriatal grafting of embryonic dopamine (DA) neurons, a pattern believed to result from decreased survival and reinn...

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Publicat a:Neurobiol Dis
Autors principals: Collier, Timothy J., O’Malley, Jennifer, Rademacher, David J., Stancati, Jennifer A., Sisson, Kellie A., Sortwell, Caryl E., Paumier, Katrina L., Gebremedhin, Kibrom G., Steece-Collier, Kathy
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4402284/
https://ncbi.nlm.nih.gov/pubmed/25771169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2015.03.005
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