Interrogating the Aged Striatum: Robust Survival of Grafted Dopamine Neurons in Aging Rats Produces Inferior Behavioral Recovery and Evidence of Impaired Integration

Advanced age is the primary risk factor for Parkinson disease (PD). In PD patients and rodent models of PD, advanced age is associated with inferior symptomatic benefit following intrastriatal grafting of embryonic dopamine (DA) neurons, a pattern believed to result from decreased survival and reinn...

Full description

Saved in:
Bibliographic Details
Published in:Neurobiol Dis
Main Authors: Collier, Timothy J., O’Malley, Jennifer, Rademacher, David J., Stancati, Jennifer A., Sisson, Kellie A., Sortwell, Caryl E., Paumier, Katrina L., Gebremedhin, Kibrom G., Steece-Collier, Kathy
Format: Artigo
Language:Inglês
Published: 2015
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4402284/
https://ncbi.nlm.nih.gov/pubmed/25771169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2015.03.005
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items