Manipulations of Amyloid Precursor Protein Cleavage Disrupt the Circadian Clock in Aging Drosophila

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by severe cognitive deterioration. While causes of AD pathology are debated, a large body of evidence suggests that increased cleavage of Amyloid Precursor Protein (APP) producing the neurotoxic Amyloid-β (Aβ) peptide plays a fund...

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Bibliographic Details
Published in:Neurobiol Dis
Main Authors: Blake, Matthew R., Holbrook, Scott D., Kotwica-Rolinska, Joanna, Chow, Eileen, Kretzschmar, Doris, Giebultowicz, Jadwiga M.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4402283/
https://ncbi.nlm.nih.gov/pubmed/25766673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2015.02.012
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