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The adaptor 3BP2 is required for KIT receptor expression and human mast cell survival
3BP2 is a cytoplasmic adaptor protein that acts as a positive regulator in mast cell FcεRI-dependent signaling. The KIT receptor whose ligand is the stem cell factor (SCF) is necessary for mast cell development, proliferation and survival as well as for optimal IgE-dependent signal. Activating mutat...
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| Publicado no: | J Immunol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4402263/ https://ncbi.nlm.nih.gov/pubmed/25810396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402887 |
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