Minocycline and Doxycycline, but not Other Tetracycline-Derived Compounds, Protect Liver Cells from Chemical Hypoxia and Ischemia/Reperfusion Injury by Inhibition of the Mitochondrial Calcium Uniporter

Minocycline, a tetracycline-derived compound, mitigates damage caused by ischemia/reperfusion (I/R) injury. Here, 19 tetracycline-derived compounds were screened in comparison to minocycline for their ability to protect hepatocytes against damage from chemical hypoxia and I/R injury. Cultured rat he...

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Pubblicato in:Toxicol Appl Pharmacol
Autori principali: Schwartz, Justin, Holmuhamedov, Ekhson, Zhang, Xun, Lovelace, Gregory L., Smith, Charles D., Lemasters, John J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4402227/
https://ncbi.nlm.nih.gov/pubmed/24012766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2013.08.027
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