Pausing of RNA polymerase II Regulates Mammalian Developmental Potential Through Control of Signaling Networks

The remarkable capacity for pluripotency and self-renewal in embryonic stem cells (ESCs) requires a finely-tuned transcriptional circuitry wherein the pathways and genes that initiate differentiation are suppressed, but poised to respond rapidly to developmental signals. To elucidate transcriptional...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Williams, Lucy H., Fromm, George, Gokey, Nolan G., Henriques, Telmo, Muse, Ginger W., Burkholder, Adam, Fargo, David C., Hu, Guang, Adelman, Karen
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4402150/
https://ncbi.nlm.nih.gov/pubmed/25773599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.02.003
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