Forward Genetics Screens Using Macrophages to Identify Toxoplasma gondii Genes Important for Resistance to IFN-γ-Dependent Cell Autonomous Immunity

Toxoplasma gondii, the causative agent of toxoplasmosis, is an obligate intracellular protozoan pathogen. The parasite invades and replicates within virtually any warm blooded vertebrate cell type. During parasite invasion of a host cell, the parasite creates a parasitophorous vacuole (PV) that orig...

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Bibliographic Details
Published in:J Vis Exp
Main Authors: Walwyn, Odaelys, Skariah, Sini, Lynch, Brian, Kim, Nathaniel, Ueda, Yukari, Vohora, Neal, Choe, Josh, Mordue, Dana G.
Format: Artigo
Language:Inglês
Published: MyJove Corporation 2015
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4401235/
https://ncbi.nlm.nih.gov/pubmed/25867017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/52556
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