Heroin Activates ATF3 and CytC via c-Jun N-Terminal Kinase Pathways to Mediate Neuronal Apoptosis

BACKGROUND: Drug abuse and addiction has become a major public health problem that impacts all societies. The use of heroin may cause spongiform leukoencephalopathy (SLE). MATERIAL/METHODS: Cerebellar granule cells were derived from 7-day-old Sprague-Dawley rat pups. Neurons were dissociated from fr...

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Detalhes bibliográficos
Publicado no:Med Sci Monit Basic Res
Main Authors: Pu, Hongwei, Wang, Xuemei, Su, Liping, Ma, Chuang, Zhang, Yan, Zhang, Liping, Chen, Xiao, Li, Xiujuan, Wang, Hua, Liu, Xiaoshan, Zhang, Jianlong
Formato: Artigo
Idioma:Inglês
Publicado em: International Scientific Literature, Inc. 2015
Assuntos:
Pharmaceutical Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4400970/
https://ncbi.nlm.nih.gov/pubmed/25848832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSMBR.893827
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