A Novel Pyruvate Kinase M2 Activator Compound that Suppresses Lung Cancer Cell Viability under Hypoxia

Pyruvate kinase M2 isoform (PKM2), a rate-limiting enzyme in the final step of glycolysis, is known to be associated with the metabolic rewiring of cancer cells, and considered an important cancer therapeutic target. Herein, we report a novel PKM2 activator, PA-12, which was identified via the molec...

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Pubblicato in:Mol Cells
Autori principali: Kim, Dong Joon, Park, Young Soo, Kim, Nam Doo, Min, Sang Hyun, You, Yeon-Mi, Jung, Yuri, Koo, Han, Noh, Hanmi, Kim, Jung-Ae, Park, Kyung Chan, Yeom, Young Il
Natura: Artigo
Lingua:Inglês
Pubblicazione: Korean Society for Molecular and Cellular Biology 2015
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4400313/
https://ncbi.nlm.nih.gov/pubmed/25813626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14348/molcells.2015.2314
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