NEMix: Single-cell Nested Effects Models for Probabilistic Pathway Stimulation

Nested effects models have been used successfully for learning subcellular networks from high-dimensional perturbation effects that result from RNA interference (RNAi) experiments. Here, we further develop the basic nested effects model using high-content single-cell imaging data from RNAi screens o...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Siebourg-Polster, Juliane, Mudrak, Daria, Emmenlauer, Mario, Rämö, Pauli, Dehio, Christoph, Greber, Urs, Fröhlich, Holger, Beerenwinkel, Niko
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4400057/
https://ncbi.nlm.nih.gov/pubmed/25879530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004078
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