Intratumoral injection of Clostridium novyi-NT spores induces antitumor responses

Species of Clostridium bacteria are notable for their ability to lyse tumor cells growing in hypoxic environments. We show that an attenuated strain of Clostridium novyi (C. novyi-NT) induces a microscopically precise, tumor-localized response in a rat orthotopic brain tumor model after intratumoral...

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Publicat a:Sci Transl Med
Autors principals: Roberts, Nicholas J., Zhang, Linping, Janku, Filip, Collins, Amanda, Bai, Ren-Yuan, Staedtke, Verena, Rusk, Anthony W., Tung, David, Miller, Maria, Roix, Jeffrey, Khanna, Kristen V., Murthy, Ravi, Benjamin, Robert S., Helgason, Thorunn, Szvalb, Ariel D., Bird, Justin E., Roy-Chowdhuri, Sinchita, Zhang, Halle H., Qiao, Yuan, Karim, Baktiar, McDaniel, Jennifer, Elpiner, Amanda, Sahora, Alexandra, Lachowicz, Joshua, Phillips, Brenda, Turner, Avenelle, Klein, Mary K., Post, Gerald, Diaz, Luis A., Riggins, Gregory J., Papadopoulos, Nickolas, Kinzler, Kenneth W., Vogelstein, Bert, Bettegowda, Chetan, Huso, David L., Varterasian, Mary, Saha, Saurabh, Zhou, Shibin
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4399712/
https://ncbi.nlm.nih.gov/pubmed/25122639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3008982
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