Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains.

The immunophilin-immunosuppressant complexes cyclophilin-cyclosporin A (CsA) and FKBP12-FK506 inhibit the phosphatase calcineurin to block T-cell activation. Although cyclophilin A, FKBP12, and calcineurin are highly conserved from yeast to man, none had previously been shown to be essential for via...

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Bibliographic Details
Main Authors: Breuder, T, Hemenway, C S, Movva, N R, Cardenas, M E, Heitman, J
Format: Artigo
Language:Inglês
Published: 1994
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC43997/
https://ncbi.nlm.nih.gov/pubmed/7515500
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