A case of EGFR mutant lung adenocarcinoma that acquired resistance to EGFR-tyrosine kinase inhibitors with MET amplification and epithelial-to-mesenchymal transition

EGFR mutant lung cancer responds to EGFR tyrosine kinase inhibitors (TKIs), but all patients eventually develop resistance to EGFR-TKIs. Herein we report a case of EGFR mutant lung adenocarcinoma that acquired resistance to EGFR-TKI with MET amplification and epithelial-to-mesenchymal transition (EM...

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Bibliographic Details
Published in:Onco Targets Ther
Main Authors: Miyoshi, Seigo, Kato, Takahide, Katayama, Hitoshi, Ito, Ryoji, Mizuno, Yosuke, Okura, Takafumi, Higaki, Jitsuo
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2015
Subjects:
Case Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4399517/
https://ncbi.nlm.nih.gov/pubmed/25914548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S78911
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