Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases.
Four inherited neurodegenerative diseases are linked to abnormally expanded repeats of glutamine residues in the affected proteins. Molecular modeling followed by optical, electron, and x-ray diffraction studies of a synthetic poly(L-glutamine) shows that it forms beta-sheets strongly held together...
Uloženo v:
| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
1994
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43993/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8202492/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.12.5355 |
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