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Transforming Growth Factor β2 Promotes Transcription of COX2 and EP4, Leading to a Prostaglandin E(2)-Driven Autostimulatory Loop That Enhances Virulence of Theileria annulata-Transformed Macrophages
Transforming growth factor beta (TGF-β) is a pleiotropic cytokine known to regulate cell growth, differentiation, and motility and is a potent modulator of immune function. TGF-β consequently plays a central role in carcinogenesis, and a dampened TGF-β2 response by Theileria annulata-infected monocy...
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| Veröffentlicht in: | Infect Immun |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4399038/ https://ncbi.nlm.nih.gov/pubmed/25690101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02975-14 |
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