CXC chemokine receptor-4 signaling limits hepatocyte proliferation after hepatic ischemia-reperfusion in mice

The role of stromal cell-derived factor-1 (SDF-1 or CXCL12) and its receptor CXC chemokine receptor-4 (CXCR4) in ischemic liver injury and recovery has not been studied. Some reports suggest that this chemokine may aid in liver regeneration, but others suggest that it may be profibrotic through its...

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Pubblicato in:Am J Physiol Gastrointest Liver Physiol
Autori principali: Wilson, Gregory C., Freeman, Christopher M., Kuethe, Joshua W., Quillin, Ralph C., Nojima, Hiroyuki, Schuster, Rebecca, Blanchard, John, Edwards, Michael J., Caldwell, Charles C., Lentsch, Alex B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2015
Soggetti:
Liver and Biliary Tract
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398844/
https://ncbi.nlm.nih.gov/pubmed/25721302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00257.2014
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