ABCC6 deficiency is associated with activation of BMP signaling in liver and kidney

Mutations in ABCC6 (ATP-binding cassette, subfamily C, member 6), an orphan transporter expressed in the liver, are the cause of pseudoxanthoma elasticum. Since ABCC6 was reported to affect matrix Gla protein (MGP), an inhibitor of bone morphogenetic proteins (BMPs), we studied BMP signaling and exp...

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Vydáno v:FEBS Open Bio
Hlavní autoři: Blazquez-Medela, Ana M., Guihard, Pierre J., Yao, Jiayi, Jumabay, Medet, Lusis, Aldons J., Boström, Kristina I., Yao, Yucheng
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398664/
https://ncbi.nlm.nih.gov/pubmed/25893161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2015.03.009
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