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Membrane-to-Nucleus Signals and Epigenetic Mechanisms for Myofibroblastic Activation and Desmoplastic Stroma: Potential Therapeutic Targets for Liver Metastasis?

Cancer associated fibroblasts (CAFs), the most abundant cells in the tumor microenvironment (TME), are a key source of extracellular matrix (ECM) that constitutes the desmoplastic stroma. Through remodeling of the reactive tumor stroma and paracrine actions, CAFs regulate cancer initiation, progress...

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Detalhes bibliográficos
Publicado no:Mol Cancer Res
Main Authors: Kang, Ningling, Shah, Vijay H., Urrutia, Raul
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398610/
https://ncbi.nlm.nih.gov/pubmed/25548101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-14-0542
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