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Dysbiosis caused by vitamin D receptor deficiency confers colonization resistance to Citrobacter rodentium through modulation of innate lymphoid cells

Vitamin D receptor (VDR) knockout (KO) mice had fewer Citrobacter rodentium in the feces than wild-type (WT) mice and the kinetics of clearance was faster in VDR KO than WT mice. VDR KO mice had more IL-22 producing innate lymphoid cells (ILC), and more anti-bacterial peptides than WT mice. The incr...

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Detalhes bibliográficos
Publicado no:Mucosal Immunol
Main Authors: Chen, Jing, Waddell, Amanda, Lin, Yang-Ding, Cantorna, Margherita T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398576/
https://ncbi.nlm.nih.gov/pubmed/25315967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2014.94
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