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Preferential Targeting of Na(v)1.6 Voltage-Gated Na(+) Channels to the Axon Initial Segment during Development

During axonal maturation, voltage-gated sodium (Na(v)) channels accumulate at the axon initial segment (AIS) at high concentrations. This localization is necessary for the efficient initiation of action potentials. The mechanisms underlying channel trafficking to the AIS during axonal development ha...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Akin, Elizabeth J., Solé, Laura, Dib-Hajj, Sulayman D., Waxman, Stephen G., Tamkun, Michael M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398423/
https://ncbi.nlm.nih.gov/pubmed/25874799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0124397
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