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Preferential Targeting of Na(v)1.6 Voltage-Gated Na(+) Channels to the Axon Initial Segment during Development

During axonal maturation, voltage-gated sodium (Na(v)) channels accumulate at the axon initial segment (AIS) at high concentrations. This localization is necessary for the efficient initiation of action potentials. The mechanisms underlying channel trafficking to the AIS during axonal development ha...

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發表在:PLoS One
Main Authors: Akin, Elizabeth J., Solé, Laura, Dib-Hajj, Sulayman D., Waxman, Stephen G., Tamkun, Michael M.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398423/
https://ncbi.nlm.nih.gov/pubmed/25874799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0124397
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