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Epoxide based inhibitors of the hepatitis C virus non-structural 2 autoprotease

Hepatitis C virus (HCV) non-structural 2 (NS2) encodes an essential protease activity responsible for processing at the NS2–NS3 junction which represents an attractive antiviral target. Attempts to inhibit the NS2 autoprotease with mechanism-based protease inhibitors and substrate peptides have had...

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Detalhes bibliográficos
Publicado no:Antiviral Res
Main Authors: Shaw, Joseph, Fishwick, Colin W.G., Harris, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398321/
https://ncbi.nlm.nih.gov/pubmed/25703928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2015.02.005
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